ESIS Research Areas
Synthesis and structure elucidation of fused heterocylic compounds;
- Benzoxazoles
- Benzothiazoles
- Benzimidazoles
- Benzoxazines
- Possible metabolites of benzoxazoles:
- Benzamides
- Phenylacetamides
- Furamides
Design of antibacterial, antifungal, antiviral, antitumor and anti-HIV active compounds;
- Gram-positive bacteria
- Gram-negative bacteria
- Fungi
- DNA-topoisomerase I inhibitory activity
- DNA-topoisomerase II inhibitory activity
- Activity against measles virus
- Genotoxic and Mutagenic activity
- Measles virus inhibitory activity
- Anti-HIV activity against HIV-1 reverse transcriptase
- Multiple drug resistantant activity:
- Apoptosis on tumor cells
- Revearsal of multidrug resistance
- Activity in multidrug-resistant variance of cancer cell lines
Computer aided drug design;
- 2D-Quantitative Structure-Activity Relationship studies:
- Hansch Analysis
- Free-Wilson Analysis
- 3D-Quantitative Structure-Activity Relationship studies:
- CoMFA Analysis
- CoMSIA Analysis
- Molecular Modelling techniques:
- Optimisation
- Pharmacophore identification and generation
- Docking