Sabiha Alper-Hayta, Ph.D.

URL : http://80.251.40.59/pharmacy.ankara.edu.tr/salper/
Email : sabiha.alper@gmail.com
Tel :

Educational and Administrative Background

2003-Present: Ph.D. Student at Ankara University Faculty of Pharmacy Department of Pharmaceutical Chemistry 
2000-2002: M.Sc. degree at Ankara University Faculty of Pharmacy Department of Pharmaceutical Chemistry
1994-1999: B.Sc., Ankara University, Faculty of Pharmacy 
1987-1994: Muğla Anadolu High School
1982-1987: Muğla Atatürk Primary School

Language Background

  • Turkish (Native Language)
  • English (Fluent)

Research Interests

Synthesis, structure elucidation and evaluation of antimicrobial and topoisomerase inhibition activity of heterocyclic molecules ((benzoxazole, benzothiazole, benzoxazine), QSAR, Molecular Modelling

Work Experience

Research Scientist, Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary, September 2005.

Memberships

  • Turkish Association of Pharmaceutical and Medicinal Chemistry 
  • Computer Aided Drug Design & Development Association in Turkey

Studies

  •  Synthesis, antimicrobial activity and QSARs of some new benzoxazole, benzimidazole, benzoxazine derivatives (Ankara University Research Fund)
  • Synthesis and determination of DNA topoisomerase inhibitor activities of some new heterocyclies and moleculer modelling studies using computer (Ankara University Research Fund)
  •  Synthesis of new aminazoles as potensial multi-drug resistance inhibitors (Turkish Scientific and Technical Research Council (TUBITAK) Research Fund)

Artículos Científicos

  • 6
    ZILIFDAR, F., ALPER-HAYTA, S., YILMAZ, S., KAPLAN-OZEN, C., FOTO, E., AYDOGAN, Z., YILDIZ, I., AKI, E., YALCIN, I., DIRIL, N., "Genotoxic potentials and eukaryotic DNA topoisomerase I inhibitory effects of some benzoxazine derivatives", Med. Chem. Res., 23(1), 480-486, (2014). DOI: 10.1007/s00044-013-0658-5 [texto íntegro]
  • 5
    KAROLAK-WOJCIECHOWSKA, J., SZCZESIO, M., ALPER-HAYTA, S., AKI, E., YALÇIN, I., "Crystal structure of 3,4-dihydro-3-oxo-6-ethoxycarbonyl-2H-1,4-benzoxazine-2-acetate, C15H17NO6", Z. Kristallogr. NCS, 225, 531-532, (2010). DOI: 10.1524/ncrs.2010.0233 [texto íntegro]
  • 4
    ALPER-HAYTA, S., ARISOY, M., TEMIZ-ARPACI, Ö., YILDIZ, I., AKI, E., ÖZKAN, S., KAYNAK, F., "Synthesis, Antimicrobial Activity, Pharmacophore Analysis of Some New 2-(Substitutedphenyl/ benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles", European Journal of Medicinal Chemistry, 43(11), 2568-2578, (2008). doi:10.1016/j.ejmech.2007.12.019 [texto íntegro]
  • 3
    OKSUZOGLU, E., TEKINER-GULBAS, B., ALPER, S., TEMIZ-ARPACI, O., ERTAN, T., YILDIZ, I., DIRIL, N., SENER-AKI, E., YALCIN, I., "Some Benzoxazoles and Benzimidazoles as DNA Topoisomerase I and II Inhibitors", Journal of Enzyme Inhibition and Medicinal Chemistry, 23(1), 37-42, (2008). DOI: 10.1080/14756360701342516 [texto íntegro]
  • 2
    OKSUZOGLU, E., TEMIZ-ARPACI, O., TEKINER-GULBAS, B., EROGLU, H., SEN, G., ALPER, S., YILDIZ, I., DIRIL, N., AKI-SENER, E., YALCIN, I., "A Study on the Genotoxic Activities of Some New Benzoxazoles", Medicinal Chemistry Research, 16, 1–14, (2007). DOI 10.1007/s00044-007-9005-z [texto íntegro]
  • 1
    ALPER-HAYTA, S., AKI-SENER, E., TEKINER-GULBAS, B., YILDIZ, I., TEMIZ-ARPACI, O., YALCIN, I., ALTANLAR, N., “Synthesis, Antimicrobial Activity and QSARs of New Benzoxazine-3-ones”, Eur. J. Med. Chem., 41(12), 1398-1404, (2006). [texto íntegro]

Artículos de Revisión

  • 1
    ALPER, S., TEMİZ-ARPACI, Ö., AKI-ŞENER, E., YALÇIN, İ.,”Some New bi-and ter-benzimidazole Derivatives as Topoisomerase I Inhibitors”, Il Farmaco, 58, 497-507, (2003). [texto íntegro]

Presentaciones Orales

  • 4
    YILDIZ, I., ALPER, S., ERTAN, T., TEMIZ-ARPACI, O., TEKINER-GULBAS, B., AKI-SENER, E., YALCIN, I., "Molecular Modeling Studies on Some Eucaryotic Topoisomerase II Enzyme Inhibitor Fused Heterocyclic Compounds", 6th AFMC International Medicinal Chemistry Symposium, Istanbul-TURKEY, July 08-11, 2007.
  • 3
    AKI-ŞENER, E., YALÇIN, İ., ALPER-HAYTA, S., TEKİNER-GÜLBAŞ; B., TEMİZ ARPACI, Ö., YILDIZ, I., ALTANLAR, N., “Synthesis, antimicrobial activity and QSARs of New Benzoxazine-3-ones”, European Conference on the Reversal of Multidrug Resistance from Bacteria to Cancer Cells and Parasites, Budapest, Hungary, Abstracts OP-10, 22-25 April 2006.
  • 2
    AKI-ŞENER, E., YALÇIN, İ., YILDIZ, İ., TEMİZ-ARPACI, Ö., ALPER, S., ZAFER, B., “Studies on Pharmacophore Group Identification of Topoisomerase II Inhibitory Active Fused Heterocyclics Using CATALYST HipHop”, The European Cost Action B16 Symposium on Multidrug Resistance Reversal, Antalya, p19, 13-14 May, 2005.
  • 1
    AKI-ŞENER, E., YALÇIN, İ., YILDIZ, I., TEMİZ ARPACI, Ö., ZAFER, B., TEKİNER-GÜLBAŞ; B., ALPER, S., “3D-QSAR Studies of Topoisomerase II Inhibitors Using Catalyst ” Watoc`05, Modelling Structure and Reactivity 7th Congress of the World Association of Theoretically Oriented Chemists, Cape Town, South Africa, Abstract C12-5, 16-21 January 2005.

Presentaciones Diapositivas

  • 1
    ALPER-HAYTA, S., ARISOY, M., TEMIZ-ARPACI, O., YILDIZ, I., AKI-SENER, E., KAYNAK-ONURDAG, F., "Synthesis and Antimicrobial Activity of Some New N-(2-Substitutedbenzoxazol-5-yl)-2-benzofurancarboxamides", Abst. P-11, 3rd International Meeting on Medicinal and Pharmaceutical Chemistry (IMMPC-3), Antalya-TURKEY, October 16-21, 2007.